|Full Name||low density lipoprotein receptor-related protein 6|
|Product Description||Rabbit Polyclonal antibody to LRP6 (low density lipoprotein receptor-related protein 6)|
|Background||The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM]|
|Synonyms||ADCAD2 antibody, FLJ90062 antibody, FLJ90421 antibody, LRP6 antibody, LRP-6 antibody, low-density lipoprotein receptor-related protein 6 antibody, low density lipoprotein receptor-related protein 6 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human LRP6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Rhesus Monkey|
|Predict Reactivity Note||Mouse (95%), Rat (98%), Zebrafish (84%), Rhesus Monkey (99%)|