|Full Name||low density lipoprotein receptor-related protein 6|
|Product Description||Rabbit Polyclonal antibody to LRP6 (phospho Ser1490) (low density lipoprotein receptor-related protein 6)|
|Background||The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM]|
|Synonyms||ADCAD2 Antibody , LRP6 Antibody , low density lipoprotein receptor-related protein 6 Antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Target||LRP6 (phospho Ser1490)|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human LRP6 (phospho Ser1490). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Rhesus Monkey|
|Predict Reactivity Note||Mouse (100%), Xenopus laevis (100%), Rhesus Monkey (100%)|