|Full Name||latent transforming growth factor beta binding protein 4|
|Product Description||Rabbit Polyclonal antibody to LTBP4 (latent transforming growth factor beta binding protein 4)|
|Background||Transforming growth factor-beta, or TGFB (see TGFB1; MIM 190180), remains biologically latent after secretion, blocked from activity by its N-terminal propeptide (the latency-associated peptide, or LAP). TGFB is activated by its dissociation from LAP. The latent form of TGFB is secreted in association with a latent TGFB-binding protein, or LTBP (see LTBP1; MIM 150390), and assembled into the extracellular matrix. LTBPs are mainly composed of epidermal growth factor (EGF; MIM 131530)-like repeats and protein domains with 8-cysteine repeats, both of which are also found in fibrillins (e.g., MIM 134797). See Oklu and Hesketh (2000) [PubMed 11104663] for a review of the LTBP gene family.[supplied by OMIM]|
|Synonyms||FLJ46318 antibody, FLJ90018 antibody, LTBP-4 antibody, LTBP4L antibody, LTBP4S antibody, LTBP4 antibody, latent-transforming growth factor beta-binding protein 4 antibody, latent transforming growth factor-beta binding protein 4L antibody, latent transforming growth factor beta binding protein 4 antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human LTBP4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (97%)|