|Full Name||nuclear receptor subfamily 1, group H, member 3|
|Product Description||Rabbit polyclonal antibody to LXR-alpha (nuclear receptor subfamily 1, group H, member 3)|
|Background||The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]|
|Synonyms||LXR-a antibody, LXRA antibody, RLD-1 antibody, NR1H3 antibody, liver X nuclear receptor alpha variant 1 antibody, oxysterols receptor LXR-alpha antibody, "nuclear receptor subfamily 1, group H, member 3 antibody"|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human LXR alpha. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Pig, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%)|