|Full Name||STE20-related kinase adaptor alpha|
|Product Description||Rabbit Polyclonal antibody to LYK5 (STE20-related kinase adaptor alpha)|
|Background||The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq]|
|Synonyms||FLJ90524 antibody, LYK5 antibody, NY-BR-96 antibody, PMSE antibody, STRAD antibody, Stlk antibody, STRADA antibody, serologically defined breast cancer antigen NY-BR-96 antibody, STE20-related adapter protein antibody, STE20-like pseudokinase antibody, STRAD alpha antibody, STE20-related kinase adapter protein alpha antibody, protein kinase LYK5 antibody, STE20-related adaptor protein antibody, STE20-related kinase adaptor alpha antibody|
|Cellular Localization||Nucleus , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human LYK5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Sheep, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (95%), Chicken (92%), Sheep (96%), Chimpanzee (100%), Bovine (96%)|