|Full Name||v-yes-1 Yamaguchi sarcoma viral related oncogene homolog|
|Product Description||Goat polyclonal antibody to LYN|
|Background||Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents. |
|Synonyms||Yamaguchi sarcoma viral (vyes1) related oncogene homolog, LYN, Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog, vyes1 Yamaguchi sarcoma viral related oncogene homolog, FLJ26625, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, JT, JTK8|
|Cellular Localization||Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinas|
|Specificity||This antibody is specific for LYN.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
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