|Product Description||Rabbit polyclonal antibody to LYRIC (metadherin)|
|Background||Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.|
|Synonyms||3D3 antibody, AEG-1 antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, MTDH antibody, protein LYRIC antibody, astrocyte elevated gene-1 protein antibody, metastasis adhesion protein antibody, 3D3/LYRIC antibody, lysine-rich CEACAM1 co-isolated protein antibody, metadherin antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Single-pass membrane protein , Nucleus membrane; Single-pass membrane protein (By similarity) , Cell junction , tight junction (By similarity) , Nucleus , nucleolus (By similarity) , Cytoplasm , perinuclear region |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human LYRIC. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Pig (93%), Rhesus Monkey (98%), Bovine (94%)|