|Full Name||lamin A/C|
|Product Description||Rabbit Polyclonal antibody to Lamin A + C|
|Background||The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]|
|Synonyms||CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, LMNA antibody, renal carcinoma antigen NY-REN-32 antibody, lamin A/C-like 1 antibody, prelamin-A/C antibody, 70 kDa lamin antibody, lamin A/C antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Lamin A/C. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Dog, Pig, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Xenopus laevis (81%), Dog (98%), Pig (98%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (98%)|