Full Name | latrophilin 1 |
Background | This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] |
Synonyms | LPHN1 Antibody , CL1 Antibody , CIRL1 Antibody , LEC2 Antibody , latrophilin 1 Antibody |
Specificity | Recognizes endogenous levels of LPHN1 protein. |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LPHN1. The exact sequence is proprietary. |
Antigen Species | Human |
Species Reactivity | Human |
Conjugation | Unconjugated |