Lck antibody [N3C3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||58 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||lymphocyte-specific protein tyrosine kinase|
|Product Description||Rabbit polyclonal antibody to Lck (lymphocyte-specific protein tyrosine kinase)|
|Background||This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq]|
|Synonyms||LSK antibody, YT16 antibody, p56lck antibody, pp58lck antibody, LCK antibody, t cell-specific protein-tyrosine kinase antibody, tyrosine-protein kinase Lck antibody, p56(LSTRA) protein-tyrosine kinase antibody, proto-oncogene tyrosine-protein kinase LCK antibody, leukocyte C-terminal Src kinase antibody, T-lymphocyte specific protein tyrosine kinase p56lck antibody, lymphocyte cell-specific protein-tyrosine kinase antibody, lymphocyte-specific protein tyrosine kinase antibody|
|Cellular Localization||Cytoplasm , Cell membrane; Lipid-anchor; Cytoplasmic side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Lck. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Sheep, Bovine|
|Predict Reactivity Note||Mouse (85%), Rat (84%), Pig (84%), Sheep (85%), Bovine (85%)|