|Full Name||mannosidase, alpha, class 1B, member 1|
|Product Description||Rabbit polyclonal antibody to MAN1B1 (mannosidase, alpha, class 1B, member 1)|
|Background||Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).|
|Synonyms||ERMan1 antibody, MANA-ER antibody, MAN1B1 antibody, "ER alpha 1,2-mannosidase antibody", "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase antibody", Man9GlcNAc2-specific processing alpha-mannosidase antibody, "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1 antibody", "mannosidase, alpha, class 1B, member 1 antibody"|
|Cellular Localization||Endoplasmic reticulum membrane; Single-pass type II membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MAN1B1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (85%)|