|Full Name||mitogen-activated protein kinase kinase kinase 8|
|Product Description||Rabbit polyclonal antibody to MAP3K8 (mitogen-activated protein kinase kinase kinase 8)|
|Background||This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq]|
|Synonyms||COT antibody, EST antibody, ESTF antibody, FLJ10486 antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, MAP3K8 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, Ewing sarcoma transformant antibody, tumor progression locus 2 antibody, proto-oncogene serine/threoine protein kinase antibody, proto-oncogene c-Cot antibody, cot (cancer Osaka thyroid) oncogene antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MAP3K8. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Bovine (98%)|