|Full Name||mitogen-activated protein kinase-activated protein kinase 3|
|Product Description||Rabbit Polyclonal antibody to MAPKAP Kinase 3 (mitogen-activated protein kinase-activated protein kinase 3)|
|Background||This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. [provided by RefSeq]|
|Synonyms||3PK antibody, MAPKAP3 antibody, MAPKAPK3 antibody, MAPKAP kinase 3 antibody, MAP kinase-activated protein kinase 3 antibody, MAPK-activated protein kinase 3 antibody, chromosome 3p kinase antibody, mitogen-activated protein kinase-activated protein kinase 3 antibody|
|Cellular Localization||Nucleus , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MAPKAP Kinase 3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (96%), Zebrafish (85%), Pig (98%), Rhesus Monkey (100%), Bovine (98%)|