|Full Name||membrane-associated ring finger (C3HC4) 2|
|Product Description||Rabbit Polyclonal antibody to MARCH2 (membrane-associated ring finger (C3HC4) 2)|
|Background||MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM]|
|Synonyms||MARCH-II antibody, RNF172 antibody, MARCH2 antibody, membrane-associated RING finger protein 2 antibody, E3 ubiquitin-protein ligase MARCH2 antibody, RING finger protein 172 antibody, membrane-associated RING-CH protein II antibody, membrane-associated ring finger (C3HC4) 2 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein , Lysosome membrane; Multi-pass membrane protein , Endosome membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MARCH2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (94%), Zebrafish (81%), Xenopus laevis (80%), Pig (95%), Bovine (91%)|