|Full Name||methyl-CpG binding domain protein 2|
|Product Description||Rabbit polyclonal antibody to MBD2 (methyl-CpG binding domain protein 2)|
|Background||DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]|
|Synonyms||DKFZp586O0821 antibody, DMTase antibody, NY-CO-41 antibody, MBD2 antibody, methyl-CpG-binding domain protein 2 antibody, demethylase antibody, methyl-CpG binding domain protein 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MBD2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Xenopus laevis (89%), Chicken (82%)|