|Full Name||methyl-CpG binding domain protein 3|
|Product Description||Rabbit polyclonal antibody to MBD3 (methyl-CpG binding domain protein 3)|
|Background||DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq]|
|Synonyms||MBD3 antibody, methyl-CpG-binding domain protein 3 antibody, methyl-CpG binding domain protein 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MBD3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Xenopus laevis (93%), Chicken (96%), Rhesus Monkey (100%), Bovine (95%)|