|Full Name||methyl-CpG binding domain protein 5|
|Product Description||Rabbit Polyclonal antibody to MBD5 (methyl-CpG binding domain protein 5)|
|Background||This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq]|
|Synonyms||FLJ11113 antibody , FLJ30517 antibody , KIAA1461 antibody , MBD5 antibody , MBD5 antibody , MRD1 antibody , methyl-CpG binding domain protein 5 antibody , methyl-CpG-binding domain protein 5 antibody , methyl-CpG-binding protein MBD5 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MBD5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (96%), Rhesus Monkey (100%), Bovine (97%)|