|Full Name||membrane-bound transcription factor peptidase, site 1|
|Product Description||Rabbit Polyclonal antibody to MBTPS1 (membrane-bound transcription factor peptidase, site 1)|
|Background||The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq]|
|Synonyms||KIAA0091 antibody, MGC138711 antibody, MGC138712 antibody, PCSK8 antibody, S1P antibody, SKI-1 antibody, MBTPS1 antibody, subtilisin/kexin-isozyme 1 antibody, membrane-bound transcription factor site-1 protease antibody, endopeptidase S1P antibody, "membrane-bound transcription factor protease, site 1 antibody", site-1 protease antibody, subtilisin/kexin isozyme-1 antibody, "membrane-bound transcription factor peptidase, site 1 antibody"|
|Cellular Localization||Endoplasmic reticulum membrane; Single-pass type I membrane protein , Golgi apparatus membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MBTPS1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Zebrafish (85%), Xenopus laevis (86%), Bovine (93%)|