|Full Name||melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)|
|Product Description||Rabbit Polyclonal antibody to MC1 Receptor (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor))|
|Background||This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]|
|Synonyms||CMM5 antibody, MGC14337 antibody, MSH-R antibody, SHEP2 antibody, MC1R antibody, melanocyte-stimulating hormone receptor antibody, melanotropin receptor antibody, melanocortin receptor 1 antibody, MC1-R antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody|
|Cellular Localization||Cell membrane; Multi-pass membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MC1 Receptor. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (100%)|