|Applications||ICC/IF, IHC-P, IP, WB, ChIP assay|
Not tested in other applications.
| ChIP assay||Assay-dependent dilution
| IHC (Formalin-fixed paraffin-embedded sections)||Assay-dependent dilution
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||293T , A431 , HeLa , HepG2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||minichromosome maintenance complex component 6|
|Product Description||Rabbit Polyclonal antibody to MCM6 (minichromosome maintenance complex component 6)|
|Background||The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. [provided by RefSeq]|
|Synonyms||MCG40308 Antibody, Mis5 Antibody, minichromosome maintenance complex component 6 Antibody, P105MCM Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human MCM6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (96%), Rhesus Monkey (100%), Bovine (97%)|