| Full Name | minichromosome maintenance complex component 6 |
| Background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. [provided by RefSeq] |
| Synonyms | MCG40308 Antibody, Mis5 Antibody, minichromosome maintenance complex component 6 Antibody, P105MCM Antibody |
| Cellular Localization | Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MCM6. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Mouse, Rat, Chicken, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Mouse (97%), Rat (97%), Chicken (90%), Rhesus Monkey (100%), Bovine (97%) |
| Conjugation | Unconjugated |