| Full Name | lymphocyte antigen 96 |
| Background | MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4. |
| Synonyms | ESOP-1, MD2 (1A2E3): Lymphocyte antigen 96 precursor, MD-2 (1A2E3): Lymphocyte antigen 96 precursor, MD2 (1A2E3): Lymphocyte antigen96 precursor, ESOP1, MD2, ESOP 1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 1A2E3 |
| Isotype | IgG1 |
| Immunogen | Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |