|Full Name||interferon induced with helicase C domain 1|
|Product Description||Rabbit Polyclonal antibody to MDA5 (interferon induced with helicase C domain 1)|
|Background||DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. [provided by RefSeq]|
|Synonyms||Hlcd antibody, IDDM19 antibody, MDA-5 antibody, MDA5 antibody, MGC133047 antibody, IFIH1 antibody, melanoma differentiation associated protein-5 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide antibody, melanoma differentiation-associated protein 5 antibody, CADM-140 autoantigen antibody, interferon-induced helicase C domain-containing protein 1 antibody, murabutide down-regulated protein antibody, RNA helicase-DEAD box protein 116 antibody, interferon-induced with helicase C domain protein 1 antibody, clinically amyopathic dermatomyositis autoantigen 140 kDa antibody, helicase with 2 CARD domains antibody, helicard antibody, interferon induced with helicase C domain 1 antibody|
|Cellular Localization||Cytoplasm , Nucleus (Potential) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MDA5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey|
|Predict Reactivity Note||Mouse (87%), Rat (87%), Pig (91%), Rhesus Monkey (98%)|