Full Name | mediator of DNA-damage checkpoint 1 |
Background | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq] |
Synonyms | DKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody, MDC1 antibody, homologue to Drosophila photoreceptor protein calphotin antibody, nuclear factor with BRCT domains 1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA damage checkpoint protein 1 antibody, mediator of DNA-damage checkpoint 1 antibody |
Cellular Localization | Nucleus |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant protein encompassing a sequence within the center region of human MDC1. The exact sequence is proprietary. |
Antigen Species | Human |
Species Reactivity | Human |
Predicted Cross Reactivity species Predicted cross-reactivity: Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive. Please note that we are only able to guarantee products to work in applications and species in which they have been tested. | Rhesus Monkey, Chimpanzee |
Predict Reactivity Note | Rhesus Monkey (96%), Chimpanzee (100%) |
Conjugation | Unconjugated |