| Full Name | mediator of DNA-damage checkpoint 1 |
| Product Description | Rabbit Polyclonal antibody to MDC1 (mediator of DNA-damage checkpoint 1) |
| Background | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq] |
| Synonyms | DKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody, MDC1 antibody, homologue to Drosophila photoreceptor protein calphotin antibody, nuclear factor with BRCT domains 1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA damage checkpoint protein 1 antibody, mediator of DNA-damage checkpoint 1 antibody |
| Cellular Localization | Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MDC1. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rhesus Monkey, Chimpanzee |
| Predict Reactivity Note | Rhesus Monkey (96%), Chimpanzee (100%) |
| Conjugation | Unconjugated |