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1 .GTX102673 MDC1 antibody [N2N3]

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MDC1 antibody [N2N3]


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsIHC-P, WB
  • Species reactivityHuman
  • Publication  ( 1 )
Cat No: GTX102673
Package Price Qty
25 μlUSD 119.00
100 μlUSD 319.00
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  • Anti-MDC1 antibody [N2N3] used in IHC (Formalin-fixed paraffin-embedded sections). GTX102673
  • Anti-MDC1 antibody [N2N3] used in Western Blot (WB). GTX102673
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  • Bio-info
  • Protocol & MSDS
  • Application Information: MDC1 antibody [N2N3]

Catalog Number GTX102673
☆☆☆☆☆
( 0 )
Publication ( 1 )
Product Name MDC1 antibody [N2N3]
See all MDC1 products
ApplicationsIHC-P, WB
Application Note
Suggested dilutionReference
IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000*  
Western Blot (WB)1:500-1:3000* Y
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Predicted Target Size227 kDa (note)
Positive ControlsHeLa nucleus
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by antigen-affinity chromatography.

  • Specifications: MDC1 antibody [N2N3]

Full Namemediator of DNA-damage checkpoint 1
BackgroundThe protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]
SynonymsDKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody, MDC1 antibody, homologue to Drosophila photoreceptor protein calphotin antibody, nuclear factor with BRCT domains 1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA damage checkpoint protein 1 antibody, mediator of DNA-damage checkpoint 1 antibody
Cellular LocalizationNucleus
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenRecombinant protein encompassing a sequence within the center region of human MDC1. The exact sequence is proprietary.
Antigen SpeciesHuman
Species ReactivityHuman
Predicted Cross Reactivity species Predicted cross-reactivity:
    Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
    Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
Rhesus Monkey, Chimpanzee
Predict Reactivity NoteRhesus Monkey (96%), Chimpanzee (100%)
ConjugationUnconjugated

  • Storage Conditions: MDC1 antibody [N2N3]

Storage Buffer1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Cell cycle > Intracellular and checkpoint control > Intra-S
  • Cell Biology > Cell cycle
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MDC1 antibody [N2N3] validated data
  • Anti-MDC1 antibody [N2N3] used in IHC (Formalin-fixed paraffin-embedded sections). GTX102673
    • GTX102673 IHC-P Image
      Immunohistochemical analysis of paraffin-embedded 59T xenograft, using MDC1(GTX102673) antibody at 1:500 dilution.
      Top
  • Anti-MDC1 antibody [N2N3] used in Western Blot (WB). GTX102673
    • GTX102673 WB Image
      Sample (30 ug of whole cell lysate)
      A: HeLa nucleus
      5% SDS PAGE
      GTX102673 diluted at 1:1000
      Top
  • Anti-MDC1 antibody [N2N3] used in IHC (Formalin-fixed paraffin-embedded sections). GTX102673
    • GTX102673 IHC-P Image
      Immunohistochemical analysis of paraffin-embedded 59T xenograft, using MDC1(GTX102673) antibody at 1:500 dilution.
      Top
  • Anti-MDC1 antibody [N2N3] used in Western Blot (WB). GTX102673
    • GTX102673 WB Image
      Sample (30 ug of whole cell lysate)
      A: HeLa nucleus
      5% SDS PAGE
      GTX102673 diluted at 1:1000
      Top
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  • Reference for MDC1 antibody [N2N3]
Application References Application Reactivity
Chen YJ et al. SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression. Sci Rep 7 (1):3842 (2017). WB Human
Target Bioinfo/ Predicted Isoform Cross Reactivity
SpeciesGene nameGene IDSwissProtOMIMIsoform (mRNA)Protein Accession#MW
Homo sapiensMDC19656A1Z5I9, Q14676607593NM_014641NP_055456226.71
    *MSDS
    MSDS-Glycerol.pdf
    MSDS-PBS.pdf
    MSDS-Thimerosal.pdf
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All products are for research use only—Not for use in diagnostic procedures.