|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||43 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||mitogen-activated protein kinase kinase 1|
|Product Description||Rabbit Polyclonal antibody to MEK1 (mitogen-activated protein kinase kinase 1)|
|Background||The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq]|
|Synonyms||MAPKK1 antibody, MEK1 antibody, MKK1 antibody, PRKMK1 antibody, MAP2K1 antibody, "protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) antibody", ERK activator kinase 1 antibody, MEK 1 antibody, MAP kinase kinase 1 antibody, MAPK/ERK kinase 1 antibody, dual specificity mitogen-activated protein kinase kinase 1 antibody, MAPKK 1 antibody, mitogen-activated protein kinase kinase 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MEK1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Dog, Pig, Rabbit, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Zebrafish (93%), Dog (100%), Pig (95%), Rabbit (100%), Chicken (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)|