|Full Name||mitogen-activated protein kinase kinase 2|
|Product Description||Mouse Monoclonal antibody [GT3522] to MEK2 (mitogen-activated protein kinase kinase 2)|
|Background||The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq]|
|Synonyms||PRKMK2 Antibody, MAPKK2 Antibody, MKK2 Antibody, MAP2K2 Antibody, mitogen-activated protein kinase kinase 2 Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MEK2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Chicken, Bovine|
|Predict Reactivity Note||Mouse (91%), Rat (92%), Dog (93%), Pig (93%), Chicken (91%), Bovine (93%)|