MEK3 antibody [N1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||39 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Raji , mouse liver|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||mitogen-activated protein kinase kinase 3|
|Product Description||Rabbit Polyclonal antibody to MEK3 (mitogen-activated protein kinase kinase 3)|
|Background||The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq]|
|Synonyms||MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, MAP2K3 antibody, MAPK/ERK kinase 3 antibody, MEK 3 antibody, SAPK kinase 2 antibody, MAP kinase kinase 3 antibody, MAPKK 3 antibody, dual specificity mitogen-activated protein kinase kinase 3 antibody, stress-activated protein kinase kinase 2 antibody, mitogen-activated protein kinase kinase 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MEK3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (97%), Xenopus laevis (80%), Chicken (90%), Rhesus Monkey (100%), Bovine (97%)|