|Full Name||mitogen-activated protein kinase kinase kinase 3|
|Product Description||Rabbit Polyclonal antibody to MEKK3 (mitogen-activated protein kinase kinase kinase 3)|
|Background||This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]|
|Synonyms||MAPKKK3 antibody, MEKK3 antibody, MAP3K3 antibody, MAP/ERK kinase kinase 3 antibody, MEKK 3 antibody, mitogen-activated protein kinase kinase kinase 3 antibody, MEK kinase 3 antibody, MAPK/ERK kinase kinase 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MEKK3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Rhesus Monkey (100%)|