|Full Name||macrophage migration inhibitory factor (glycosylation-inhibiting factor)|
|Product Description||Goat polyclonal antibody to MIF|
|Background||Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
|Synonyms||macrophage migration inhibitory factor (glycosylation-inhibiting factor), macrophage migration inhibitory factor, MMIF, MIF, GIF, macrophage migration inhibitory factor (glycosylationinhibiting factor), GLIF, HGNC:7097, phenylpyruvate tautomerase|
|Cellular Localization||Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. |
|Specificity||This antibody is specific for MIF.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.