|Full Name||mutL homolog 3 (E. coli)|
|Product Description||Rabbit Polyclonal antibody to MLH3 (mutL homolog 3 (E. coli))|
|Background||This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]|
|Synonyms||HNPCC7 antibody, MGC138372 antibody, MLH3 antibody, DNA mismatch repair protein Mlh3 antibody, mutL protein homolog 3 antibody, mutL homolog 3 (E. coli) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human MLH3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey|
|Predict Reactivity Note||Mouse (89%), Rat (88%), Rhesus Monkey (97%)|