|Full Name||matrix metallopeptidase 13 (collagenase 3)|
|Product Description||Rabbit Polyclonal antibody to MMP13 (matrix metallopeptidase 13 (collagenase 3))|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]|
|Synonyms||CLG3 antibody, MANDP1 antibody, MMP13 antibody, matrix metalloproteinase 13 (collagenase 3) antibody, MMP-13 antibody, collagenase 3 antibody, matrix metallopeptidase 13 (collagenase 3) antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP13. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rabbit (100%)|