|Full Name||matrix metallopeptidase 24 (membrane-inserted)|
|Product Description||Rabbit Polyclonal antibody to MMP24 (matrix metallopeptidase 24 (membrane-inserted))|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq]|
|Synonyms||matrix metallopeptidase 24 (membrane-inserted) Antibody, MT5MMP Antibody, MMP25 Antibody, MTMMP5 Antibody, MT5-MMP Antibody, MT-MMP 5 Antibody, MMP-24 Antibody, MT-MMP5 Antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein; Extracellular side , Processed matrix metalloproteinase-24: Secreted , extracellular space , extracellular matrix (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human MMP24. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (83%)|