MMP3 antibody [N3C1], Internal
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||54 kDa (note)
|Positive Controls||293T , A431 , H1299 , HelaS3 , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||matrix metallopeptidase 3 (stromelysin 1, progelatinase)|
|Product Description||Rabbit Polyclonal antibody to MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase))|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]|
|Synonyms||CHDS6 antibody, MGC126102 antibody, MGC126103 antibody, MGC126104 antibody, MMP-3 antibody, SL-1 antibody, STMY antibody, STMY1 antibody, STR1 antibody, MMP3 antibody, matrix metalloproteinase-3 antibody, transin-1 antibody, "matrix metalloproteinase 3 (stromelysin 1, progelatinase) antibody", proteoglycanase antibody, stromelysin-1 antibody, "matrix metallopeptidase 3 (stromelysin 1, progelatinase) antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP3. The exact sequence is proprietary.|