|Full Name||murine retrovirus integration site 1 homolog|
|Product Description||Rabbit Polyclonal antibody to MRVI1 (murine retrovirus integration site 1 homolog)|
|Background||This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq]|
|Synonyms||IRAG antibody, JAW1L antibody, MRVI1 antibody, JAW1-related protein MRVI1 antibody, "inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate antibody", IP3R-associated cGMP kinase substrate antibody, protein MRVI1 antibody, murine retrovirus integration site 1 homolog antibody|
|Cellular Localization||Cytoplasm , perinuclear region , Sarcoplasmic reticulum (By similarity) , Membrane; Single-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human MRVI1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (86%), Bovine (88%)|