|Applications||ELISA, FACS, ICC/IF, IHC-F, IHC-P, WB|
|Application Note||WB(1:100-500), ELISA(1:500-1000), IHC-P(1:100-500), IHC-F(1:100-500), FACS(1:100-500), IF(1:100-500)|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by Protein A and peptide affinity chromatography.|
|Full Name||macrophage scavenger receptor 1|
|Product Description||Rabbit Polyclonal antibody to MSR1|
|Background||This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for|
|Synonyms||SRA Antibody, SR-A Antibody, SCARA1 Antibody, phSR2 Antibody, phSR1 Antibody, CD204 Antibody, macrophage scavenger receptor 1 Antibody|
|Immunogen||KLH conjugated synthetic peptide derived from human MSR1/CD204 (230-276aa)|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Rabbit, Horse, Dog|