|Full Name||metastasis associated 1 family, member 2|
|Product Description||Rabbit polyclonal antibody to MTA2 (metastasis associated 1 family, member 2)|
|Background||This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq]|
|Synonyms||DKFZp686F2281 antibody, MTA1L1 antibody, PID antibody, MTA2 antibody, metastasis-associated 1-like 1 antibody, p53 target protein in deacetylase complex antibody, metastasis-associated protein MTA2 antibody, metastasis -associated gene 1-like 1 antibody, metastasis-associated protein 2 antibody, MTA1-L1 protein antibody, "metastasis associated gene family, member 2 antibody", "metastasis associated 1 family, member 2 antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MTA2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey|
|Predict Reactivity Note||Mouse (83%), Rhesus Monkey (92%)|