MTGR1 antibody [C1C3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||67 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||core-binding factor, runt domain, alpha subunit 2; translocated to, 2|
|Product Description||Rabbit polyclonal antibody to CBFA2T2 (core-binding factor, runt domain, alpha subunit 2; translocated to, 2)|
|Background||In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]|
|Synonyms||DKFZp313F2116 antibody, EHT antibody, MTGR1 antibody, ZMYND3 antibody, p85 antibody, CBFA2T2 antibody, myeloid translocation gene-related protein 1 antibody, MTG8-like protein antibody, MTG8-related protein 1 antibody, ETO homolog on chromosome 20 antibody, myeloid translocation-related protein 1 antibody, ETO homologous on chromosome 20 antibody, protein CBFA2T2 antibody, "core-binding factor, runt domain, alpha subunit 2, translocated to, 2 antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human MTGR1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Chicken (80%)|