| Full Name | mucin 1, cell surface associated |
| Background | This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] |
| Synonyms | PUM Antibody , MUC1\/SEC Antibody , MUC1/ZD Antibody , H23AG Antibody , KL6 Antibody , EMA Antibody , CA\ 153 Antibody , PEMT Antibody , PEM Antibody , CD227 Antibody , MAM6 Antibody , MUC1\/X Antibody |
| Cellular Localization | Cell Membrane and Cytoplasmic |
| Specificity | Repeat of VNTR extracellular portion of MUC1 molecule. Reacts with VNTR5 and VNTR20†recombinant unglycosylated fragments of MUC1 protein and underglycosylated MUC1. Does not recognize natural MUC1 protein isolated from human milk by affinity purification on carbohydrate. Belongs to Mab cluster 1-4 according to ISOMB TD-4 classification . No cross-reactivity with egg white avidin. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | M10G4 |
| Isotype | IgG |
| Immunogen | Full length protein (Human). A high molecular weight, more than 300 kDa, glycoprotein from human milk-fat globule molecule. |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Unconjugated |