| Full Name | mucin 1, cell surface associated |
| Product Description | Mouse monoclonal [M10G4] to MUC1 |
| Background | This antibody reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acid tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of this antibody is the 8-mer SAPDTRPA of the MUC1 tandem repeat as established with epitope fingerprinting. |
| Synonyms | mucin, PEMT, MUC1, PUM, 4582, 158340, P15941, EMA, PEM, H23AG, MAM6, CD227 |
| Cellular Localization | Cell Membrane and Cytoplasmic |
| Specificity | Repeat of VNTR extracellular portion of MUC1 molecule. Reacts with VNTR5 and VNTR20†recombinant unglycosylated fragments of MUC1 protein and underglycosylated MUC1. Does not recognize natural MUC1 protein isolated from human milk by affinity purification on carbohydrate. Belongs to Mab cluster 1-4 according to ISOMB TD-4 classification . No cross-reactivity with egg white avidin. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | M10G4 |
| Target | MUC1 |
| Isotype | IgG |
| Immunogen | Full length protein (Human). A high molecular weight, more than 300 kDa, glycoprotein from human milk-fat globule molecule. |
| Antigen Species | Human |
| Species Reactivity | Human |