|Full Name||muscle, skeletal, receptor tyrosine kinase|
|Product Description||Rabbit Polyclonal antibody to MUSK (muscle, skeletal, receptor tyrosine kinase)|
|Background||Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM]|
|Synonyms||MGC126323 antibody, MGC126324 antibody, MUSK antibody, muscle-specific kinase receptor antibody, "muscle, skeletal receptor tyrosine-protein kinase antibody", muscle-specific tyrosine-protein kinase receptor antibody, "muscle, skeletal, receptor tyrosine kinase antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human MUSK. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (98%), Bovine (97%)|