|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||99 kDa (note)
|Positive Controls||Molt-4 , Neuro2A , GL261 , C8D30 , BCL-1 , Raw264.7|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||major vault protein|
|Product Description||Rabbit Polyclonal antibody to MVP/LRP (major vault protein)|
|Background||This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq]|
|Synonyms||LRP antibody, VAULT1 antibody, MVP antibody, lung resistance-related protein antibody, major vault protein antibody|
|Cellular Localization||Cytoplasm , Nucleus , nuclear pore complex |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human MVP/LRP. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Cat, Bovine|
|Predict Reactivity Note||Rat (90%), Dog (91%), Cat (93%), Bovine (88%)|