| Full Name | myosin VI |
| Product Description | Rabbit Polyclonal antibody to MYO6 |
| Background | Myosins belong to a superfamily of actin based motor proteins comprising at least 15 or more classes. There are two main groups of myosins: the conventional (class II) and the unconventional myosins. Myosin VI is a relatively abundant widespread unconventional myosin composed of an N-terminal motor domain, a light chain binding neck region, a coil-coiled region, and a highly conserved C-terminal domain. At the converter region between the catalytic head and the neck region of myosin VI, there is a characteristic linker of approximately 50 amino acids. Native myosin VI is apparently a two-headed dimer of the heavy chains with each heavy chain bound to calmodulin light chain. Myosin VI is a unique reverse actin motor in vitro i.e. to display motility towards the pointed (minus) ends of actin filaments, a direction opposite to all other currently known myosins. |
| Synonyms | MYR12, MYO5A, Q9Y4I1, 160777, MYO6, myosin Va, MYH12, myosin V, GS1, MYO5, MYOXIN, 4644 |
| Cellular Localization | Cell Membrane, Cytoplasmic and Golgi Apparatus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | MYO6 |
| Isotype | IgG |
| Immunogen | synthetic peptide corresponding to an epitope within the C-terminal of human Myosin VI, with N-terminal cysteine added, conjugated to KLH. |
| Antigen Species | Human |
| Species Reactivity | Dog, Rat |
| Conjugation | Unconjugated |