|Full Name||H2A histone family, member Y2|
|Product Description||Rabbit Polyclonal antibody to Macro H2A.2 (H2A histone family, member Y2)|
|Background||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. |
|Synonyms||macroH2A2 antibody, H2AFY2 antibody, core histone macro-H2A.2 antibody, mH2A2 antibody, core histone macroH2A2.2 antibody, histone macroH2A2 antibody, "H2A histone family, member Y2 antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Macro H2A.2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (99%), Chicken (94%), Rhesus Monkey (100%), Bovine (100%)|