|Full Name||chymase 1, mast cell|
|Product Description||Rabbit Polyclonal antibody to Mast Cell Chymase (chymase 1, mast cell)|
|Background||This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq]|
|Synonyms||CYH antibody, MCT1 antibody, MGC119890 antibody, MGC119891 antibody, chymase antibody, CMA1 antibody, mast cell protease I antibody, "chymase, heart antibody", alpha-chymase antibody, "chymase, mast cell antibody", chymase 1 preproprotein transcript I antibody, chymase 1 preproprotein transcript E antibody, "chymase 1, mast cell antibody"|
|Cellular Localization||Secreted , Cytoplasmic granule |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Mast Cell Chymase. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (97%)|