Melatonin Receptor 1A antibody

Name: Melatonin Receptor 1A antibody
Brand: GeneTex
SKU: GTX100003
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-Melatonin Receptor 1A antibody used in Western Blot (WB). GTX100003

Anti-Melatonin Receptor 1A antibody used in IHC (Paraffin sections) (IHC-P). GTX100003

Cat. No. GTX100003

Reference 6

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P
Reactivity	Sheep, Japanese Medaka, Carp
Package	100 μl ($399), 25 μl ($169)

See all Melatonin Receptor 1A products

View product citations for antibody GTX100003 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500-1:3000
ICC/IF	Assay dependent
IHC-P	Assay dependent

Not tested in other applications.

Calculated MW

39 kDa. ( Note )

Predict Reactivity

Human, Mouse, Chicken(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of human Melatonin Receptor 1A. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1241048

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

melatonin receptor 1A , MEL-1A-R , MT1

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq]

Database

Gene ID: 4543 MTNR1A
UniProt: P48039 MTNR1A

Research Area

DATA IMAGES

GTX100003 WB Image

The data was published in the journal Int J Mol Sci in 2017. PMID: 28335493

GTX100003 IHC-P Image

The data was published in the journal Int J Mol Sci in 2017. PMID: 28335493

REFERENCE

Application Reference

Sasaki H et al. Am J Physiol Lung Cell Mol Physiol 2021; 321 (6) : L991-L1005 Melatonin MT(2) receptor is expressed and potentiates contraction in human airway smooth muscle.

Application : WB

Gonzalez-Arto M et al. Int. J. Mol. Sci. 2017; 18 (3) : 662 Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract.

Application : WB, IHC-P

Reactivity : Sheep

Gonzalez-Arto M et al. Theriogenology 2016; (Epub) Melatonin receptors MT₁ and MT₂ are expressed in spermatozoa from several seasonal and nonseasonal breeder species.

Application : WB

Ogiwara K et al. Biol Reprod 2016; A Dual Role for Melatonin in Medaka Ovulation: Ensuring Prostaglandin Synthesis and Actin Cytoskeleton Rearrangement in Follicular Cells.

Application : WB

Reactivity : Japanese Medaka

Kepka M et al. Dev Comp Immunol 2015; 53 (1) : 179-90 A role for melatonin in maintaining the pro- and anti-inflammatory balance by influencing leukocyte migration and apoptosis in carp.

Application : ICC/IF

Reactivity : Carp

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