Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||70 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||neurofibromin 2 (merlin)|
|Product Description||Rabbit Polyclonal antibody to Neurofibromin 2 (neurofibromin 2 (merlin))|
|Background||This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq]|
|Synonyms||ACN antibody, BANF antibody, SCH antibody, NF2 antibody, moesin-ezrin-radixin-like protein antibody, moesin-ezrin-radixin like antibody, schwannomin antibody, neurofibromin-2 antibody, merlin antibody, neurofibromin 2 (bilateral acoustic neuroma) antibody, moesin-ezrin-radizin-like protein antibody, schwannomerlin antibody, neurofibromin 2 (merlin) antibody|
|Cellular Localization||Isoform 1: Cell projection , filopodium membrane; Peripheral membrane protein; Cytoplasmic side , Cell projection , ruffle membrane; Peripheral membrane protein; Cytoplasmic side , Isoform 7: Cytoplasm , perinuclear region , Cytoplasmic granule , Isoform |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Neurofibromin 2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Chicken, Rhesus Monkey|
|Predict Reactivity Note||Chicken (95%), Rhesus Monkey (97%)|