|Full Name||mind bomb|
|Product Description||Rabbit Polyclonal antibody to Mib (mind bomb)|
|Background||E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development. |
|Synonyms||fe47f05 Antibody , wu:fe47f05 Antibody , mind bomb Antibody , im:7148100 Antibody , cg5841 Antibody , chunp6889 Antibody , mib1 Antibody , mib Antibody|
|Cellular Localization||Cytoplasm , Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of zebrafish Mib. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Drosophila, Bovine|
|Predict Reactivity Note||Human (97%), Mouse (97%), Rat (97%), Drosophila (80%), Bovine (97%)|