|Full Name||MRE11 meiotic recombination 11 homolog A (S. cerevisiae)|
|Product Description||Rabbit Polyclonal antibody to Mre11 (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))|
|Background||This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||ATLD antibody, HNGS1 antibody, MRE11 antibody, MRE11B antibody, MRE11A antibody, double-strand break repair protein MRE11A antibody, MRE11 homolog A antibody, meiotic recombination 11 homolog A antibody, MRE11 homolog 1 antibody, AT-like disease antibody, DNA recombination and repair protein antibody, endo/exonuclease Mre11 antibody, meiotic recombination 11 homolog 1 antibody, MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody|
|Cellular Localization||Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Mre11. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (86%), Rat (86%), Bovine (90%)|