|Full Name||muscleblind-like (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to Muscleblind-like 1 (muscleblind-like (Drosophila))|
|Background||Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.|
|Synonyms||DKFZp686P06174 antibody, EXP antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody, KIAA0428 antibody, MBNL antibody, MBNL1 antibody, triplet-expansion RNA-binding protein antibody, muscleblind-like protein 1 antibody, muscleblind-like (Drosophila) antibody|
|Specificity||Knockdown/Knockout validation was supported by references (PMID:26991005)|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Muscleblind-like 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (92%), Chicken (98%), Bovine (92%)|