|Product Description||Rabbit Polyclonal antibody to Myotilin (myotilin)|
|Background||This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.|
|Synonyms||LGMD1 antibody, LGMD1A antibody, TTID antibody, MYOT antibody, myotilin antibody, titin immunoglobulin domain protein (myotilin) antibody, 57 kDa cytoskeletal protein antibody, myofibrillar titin-like Ig domains protein antibody|
|Cellular Localization||Cell membrane , sarcolemma , Cytoplasm , cytoskeleton , myofibril , sarcomere , Z-disk |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Myotilin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (94%), Pig (95%), Bovine (95%)|