|Full Name||neuroblastoma RAS viral (v-ras) oncogene homolog|
|Product Description||Rabbit Polyclonal antibody to N-Ras (neuroblastoma RAS viral (v-ras) oncogene homolog)|
|Background||This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq]|
|Synonyms||ALPS4 antibody, N-ras antibody, NRAS1 antibody, NS6 antibody, NRAS antibody, N-ras protein part 4 antibody, GTPase NRas antibody, v-ras neuroblastoma RAS viral oncogene homolog antibody, transforming protein N-Ras antibody, neuroblastoma RAS viral (v-ras) oncogene homolog antibody|
|Cellular Localization||Cell membrane; Lipid-anchor; Cytoplasmic side , Golgi apparatus membrane; Lipid-anchor |
|Specificity||Cross-reactivity may occur with other RAS proteins|
|Immunogen||Full length human N-Ras Recombinant protein.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Dog, Pig, Chicken, Bovine, Guinea pig|
|Predict Reactivity Note||Rat (99%), Zebrafish (90%), Xenopus laevis (92%), Dog (100%), Pig (100%), Chicken (96%), Bovine (100%), Guinea pig (99%)|